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Vitamin D deficiency is more than just a common nutritional issueit has significant clinical implications, from weakened bones to compromised immune function

10.1186/s12931-016-0343-6 95 PengD.FuM.WangM.WeiY.WeiX

Inflammation ROS exerts its effects by activating various targets, including NFB, HIF-1, and the NLRP3 inflammasome, to drive inflammation, a critical factor in atherogenesis [278]

All controlled studies referenced below were conducted in cell culture (3T3-L1 adipocytes, primary muscle stem cells) or rodent models (diet-induced obese mice, aged C57BL/6J mice)

Intriguingly, approximately half of the MCT4-downregulated animals also lost their BOLD response, and this deficit could be rescued by peripheral lactate infusion, a rescue not possible in MCT2-downregulated rats