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However, the specific knockout of KLF4 in AdvSca1-SM cells induces it to differentiate into a more protective cell phenotype, and enhances plaque stability by changing plaque composition (such as reducing necrotic core and increasing fiber cap thickness), thus inhibiting atherosclerosis from developing toward instability (106)
Lee CL, Chiu PC, Hautala L, Salo T, Yeung WS, Stenman UH et al (2013) Human chorionic gonadotropin and its free -subunit stimulate trophoblast invasion independent of LH/hCG receptor

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During drug and alcohol detox, oxidative damage and inflammation are heightened
The OH depolymerizes GI mucin, inactivates pyruvate dehydrogenase, an essential mitochondrial enzyme, and damages mitochondrial RNA and DNA in the GI tract (113)
