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The net result of these actions is inhibition of C-fibre-evoked postsynaptic excitation, although TRPA1-mediated calcium influx may initially increase spontaneous excitatory postsynaptic currents via activation of ionotropic glutamate receptors (iGluR)

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ACKNOWLEDGMENTS JV, BV, DM, and MS performed the surgery and conducted the assessments

This strategy considers the bodys natural rhythms, which can influence how patients metabolize drugs and how tumors respond to treatment