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In a cerebral ischemia rat model, Lin et al (206) observed that serum glucose-oxygen deprivation significantly increases microglial LD accumulation, concurrent with elevated release of inflammatory mediators TNF- and IL-1
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It is generally believed that low concentrations of this solvent are safe and have antioxidant and/or protective effects for cellular structures and processes, whereas high concentrations can be harmful
Further clinical studies should focus on optimizing dosage, bioavailability, and potential synergy with other oncology treatments
