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The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene

When mitochondrial function is impaired, such as reduced ATP production, mitochondrial deoxyribonucleic acid (mtDNA) mutation, OXPHOS dysfunction, overproduction of mitochondrial reactive oxygen species (mtROS) and abnormal accumulation of some intermediates

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Thus, experiments with ovariectomized (OVX) rats have shown a reduction in the anti-oxidant activity of superoxide dismutase (SOD) in the hippocampus, a process that contrasts with an increase in the pro-oxidant enzyme monoamine oxidase (MAO) in the same region (Huang and Zhang, 2010)

Gampper, L
