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Description
Fer-1, DFO, Lip-1, RSL3, Z-VAD-FMK and MT were dissolved in dimethylsulfoxide (DMSO) and diluted in a culture medium at ultimate concentrations (0.5 M with RSL3
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This approach not only potentiated apoptosis but also blocked compensatory survival pathways, supporting its potential to overcome resistance in MSS CRC [160]
Depletion of NAD pool contributes to impairment of endothelial progenitor cell mobilization in diabetes
AR inhibition prevented growth factor-induced proliferation of colon cancer cells by arresting cells in the G1 phase, blocking phosphorylation of retinoblastoma protein and cyclin-dependent kinase (cdk)-2, and downregulating the expression of proliferating cell nuclear antigen (PCNA), cyclin D1, cyclin E, cdk4, and c-myc [120,121]
