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These findings underscore the critical role of anionic composition in Mg supplementation for optimizing region-specific therapeutic outcomes

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

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An increase in selenoproteins was expected because we have some indications that DPDS can be metabolized into inorganic selenium and, consequently, could be incorporated into selenoproteins in the form of the amino acid selenocysteine (SeCys) or produce inorganic Se (particularly HSe- or selenide), which has anticancer activity [16, 19, 95,96,97]

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