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Angiotensin I-converting enzyme (ACE, CD143) hydrolyzes small peptides such as angiotensin I, bradykinin, substance P, LH-RH and several others and thus plays a key role in blood pressure regulation and vascular remodeling

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The resultant supernatant was deproteinized by adding 50% v/v of freshly prepared 10% metaphosphoric acid followed by a 5-min incubation at room temperature

Further investigation also determined that CHMP2A KO concurrently increased NFkB and, although only shown in Cal27 cells, decreased soluble TNF-related apoptosis-inducing ligand (TRAIL) and MHC class 1 chain-related protein (MIC)A and MICB levels [104]