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Because there are many health conditions that can cause extreme fatigue, other testing must be done to rule out potential underlying causes, such as: Thyroid dysfunction Nerve disorders Nutrient Deficiencies Cortisol saliva testing or blood tests may be ordered by your healthcare provider
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* Vitamin B 12 deficiency is associated with either long-term proton inhibitor (PPI) or Histamine-2 receptor blocker (H 2 blocker) use, but a causal relationship is not established
