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How This Works Des(13) IGF1 is a truncated IGF1 analog designed/observed to: Retain affinity for IGF1 receptor (IGF1R) Interact differently with IGF binding proteins (IGFBPs), often described as lower binding, which can increase free fraction in experimental settings

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These observations, together with the fact that spine head size and geometry are associated with AMPA receptor content and maturation status (Matsuzaki et al., 2001), suggest that MET signaling may control many aspects of glutamatergic synapse development, including the timing of excitatory synapse maturation (Qiu et al., 2014)

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