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Monoamine Oxidase (MAO) Inhibition: Although its clinical relevance is debated, at high doses amphetamine acts as a weak competitive inhibitor of monoamine oxidase, the mitochondrial enzyme responsible for degrading free cytosolic monoamines

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The bibliographies of retrieved papers identified in the search were manually searched for additional relevant articles, and recent recommendations and treatment guidelines were also considered for inclusion
those with a higher metabolic rate might notice the effects sooner

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