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Although it isnt FDA-approved for general weight loss, some people use it off-label

Selenium is not only an integral component of the synthesis and metabolism of thyroid hormones but also plays a unique role in the thyroid gland (81)

Chemopreventive effects of silibin were evaluated on colitis-associated cancer (CAC) mouse model, finding that this component significantly inhibited intestinal tumor cell viability, reduced tumor size and number, decreased colitis and tumor scores, and promoted apoptosis while inhibiting proliferation [580]

The isoenzyme pattern in human is well-characterized with the liver and intestine expressing CES1 and CES2 respectively

A B12 deficiency can also cause megaloblastic anemia, a condition where red blood cells are too large and do not function properly
