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13 BrunettiP.ZanellaL.De PaolisA.Di LittaD.CecchettiV.FalascaG.et al (2015)

While Cu(I)/Cu(II) redox cycling is essential for the catalytic activity of cuproenzymes, copper-binding proteins and organocopper compounds involved in intracellular copper trafficking must avoid such redox cycling to prevent toxicity (Andrei et al

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Arch Toxicol 2017;91:378797

50 Nebulized formoterol significantly increased trough FEV 1 versus placebo over 12 weeks and had efficacy and safety profiles similar to formoterol administered via a DPI