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Description
The corresponding cysteine S- conjugate, S- (2-chloro-1,1,2-trifluoroethyl)-L-cysteine (CTFC) is also nephrotoxic in rats and cytotoxic in isolated kidney cells, and its bioactivation is dependent on metabolism by renal -lyase (Dohn et al., 1985b)
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Currently, the preclinical development of these strategies appears more challenging to avoid strong side effects, but the expected results are commensurate with patients hopes for treatments
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