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Satralizumab: first approval
Oligodendrocytes and OPCs are particularly vulnerable to oxidative stress due to their extremely high metabolic demand needed for the endogenous production of myelin and their decreased ability to deal with free radicals (French et al., 2009
Routes of Administration Subcutaneous injection (community protocol): Community sources describe the abdomen, love handles, and thighs areas with subcutaneous fat as the typical injection sites, at a volume of approximately 0.1 mL using a 29-31 gauge insulin syringe
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