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Extensive evidence highlights its key safety characteristics: No genotoxic or mutagenic activity: The JofEM study [2] on AOD 9604 reported no genotoxic effects in rats and cynomolgus monkeys during Ames, chromosomal aberration, and bone micronucleus assays

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Recent studies have demonstrated that mtDNA can undergo cytosine methylation at both CpG and non-CpG sites, including within regulatory regions such as the D-loop [30]

Tirzepatide : Marketed as Mounjaro (diabetes) and Zepbound (obesity), tirzepatide combines GLP-1 and GIP receptor agonism, achieving up to 22% weight loss , the highest among approved drugs