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While in S + M group it can be explained as a consequence of identical changes in liver and serum, in I/R and I/R + M groups, it is probably the result of impaired adrenal catecholamine synthesis

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Chronobiology reframes therapeutic timing: administering C-C chemokine receptor 2 (CCR2) antagonists aligned with circadian rhythms of immune cell trafficking could enhance efficacy while respecting individual sleep-wake cycles, critical for patients whose work schedules disrupt circadian alignment [249]