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S.SorciL.AsressS.et al (2006)

At the same time, studies which evaluated a profile aimed at neuroinflammation suggest ALA doses of 100 to 200 mg/kg to inhibit inflammatory pathways in the central nervous system, such as the mitogen activated protein kinase (MAPK) signaling pathway, related to the ERK, JNK and NF-kB pathways

Elevate homocysteine levels, impairing normal blood vessel function, promoting oxidative stress, and increasing risk of atherosclerosis, cardiovascular disease, insulin resistance, and Type 2 diabetes

This mechanism underpins the primary therapeutic role of OVs, while additional modulation of the tumor microenvironment (TME), including macrophage polarization, has emerged as an ancillary benefit (202204)

Xue L, Yu D, Wang L, Sun J, Song Y, Jia Y, et al