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EMA Decision P/0336/2024 Paediatric Investigation Plan for retatrutide

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Rituximab, a monoclonal antibody targeting the CD20 antigen, depletes CD20-positive B lymphocytes through antibody-dependent cell-mediated cytotoxicity (ADCC), complement-mediated cytotoxicity (CDC), antibody-dependent cellular phagocytosis (ADCP), and programmed cell death (PD), providing a robust rationale for its use in treating SLE (114, 115)

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Opportunity to draw from an array of individuals and backgrounds to ensure shared values of equity that improve institutional decision-making