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10.1038/nm.4010 [DOI] [PMC free article] [PubMed] [Google Scholar] 27.Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, OHara SP, LaRusso NF, Miller JD, et al

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Interestingly, these IGF1R mutants with lower negative cooperativity in IGF1 binding showed slightly weaker activation in response to IGF1 (Fig
