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The peptide is composed of a chain of 15 amino acids (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val)

Maximum: 20 mg daily Extended release Initial: 2.55 mg once daily with first main meal Maximum: 20 mg daily Glimepiride (Amaryl) Dosage Initial: 12 mg once daily with first main meal Maximum: 8 mg daily Possible side effects include: Hypoglycemia Weight gain Meglitinides (glinides) Primary mechanism(s) of action Meglitinides stimulate insulin release by pancreatic beta cells

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Briefly, fluorinated octyl maltoside (Anatrace, O310F) was added to a final concentration of 0.7 mM to cryo-EM samples (3 L for each sample