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The effects of inflammation on neurotransmitter production (reduced serotonin production, increased quinolinic acid production) also create a tendency towards mood and behavioural changes, often diagnosed as depression and anxiety

Although opioid agonist drugs do not typically produce strong subjective effects at low doses (Hanks, ONeill, Simpson, Wesnes, 1995), changes in self-reported mood and arousal are typically reported in many of the studies reviewed, most consistently at higher doses

Sleep Disturbances: Difficulty falling asleep or staying asleep

Shock 2010

MOTS-c does not produce acute effects after a single injection