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Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development

Evaluating diverse administration paradigms in zebrafish larvae is essential for elucidating the uptake, transport, metabolism, and efficacy of therapeutic agents, including both small molecule drugs and cell-based therapies (Figure 4A) (Figure 4B) (Molina et al., 2021)

The dose chart provides the framework, but individual optimization requires attention to both efficacy markers and tolerability signals

All authors contributed to the discussions and data interpretation that were used to form the review contained in this paper and provided input to the manuscript and approved its final version

Meanwhile, Anderson et al