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There are a range of perturbations that result in the loss of proteostasis, including genetic mutations that alter amino acid sequences, errors during protein synthesis and post-translational modifications (PTMs), dysfunction of the molecular chaperones responsible for assisting protein folding, and various cellular stresses, such as heat shock, oxidative stress, and nutrient deprivation

Pediatr Int 54(6):801805 Arai K, Lee F, Miyajima A, Miyatake S, Arai N, Yokota T (1990) Cytokines: coordinators of immune and inflammatory responses

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[PubMed] [Google Scholar] [29].Herzenberg LA, DeRosa SC, Dubs JG, Roederer M, Anderson MT, Ela SW, et al