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Alternatively, fumaric acid can be synthesized via chemical oxidation of benzene derivatives , though fermentation-based production is preferred for food and pharmaceutical applications due to its safety profile

Neurons are particularly vulnerable to oxidative damage in the presence of OS and NS because of several factors involving, among others, the presence of large amounts of polyunsaturated fatty acids in their lipid bilayers, the high dependence on paramagnetic oxygen for neuronal survival, and the high metabolic rate of neurons and glia with attendant free radical leak from mitochondria (8)

St Johns wort and depression: efficacy, safety and tolerability: an update

doi: 10.1042/bj1700285

( k ) RAD51 foci were quantified in Kuramochi cells treated with cisplatin alone or in combination with KG, l-carnitine, or O-acetyl-l-carnitine (n = 3 technical replicates representative from 2 independent experiments)