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However, for rats treated with high doses of curcumin, IL-1 and oxidised protein levels were reduced whereas no significant difference in A deposition was observed thus indicating that the mechanism of action of curcumin had different dose requirements that could counterbalance each other at higher dosages [296]

So from zero, no testosterone, which is chemically castrated, you're miserable, you have no sexual function, you're at increased risk of all these other chronic diseases that can kill you

In: Sen CK, Packer L, Hnninen OOP (eds.) Handbook of Oxidants and Antioxidants in Exercise, Part III, Chapter 7

[DOI] [PMC free article] [PubMed] [Google Scholar] [35].Petris MJ, Smith K, Lee J, et al

RBCs, Red Blood Cells