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Administration of general anesthetics might increase the level of ROS by elevating partial pressure of brain tissue oxygen of neonates, then disrupt cognitive functions in immature brains ( Well-balanced ROS and antioxidants is crucial to the proper development of the central nervous system

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PMID: 9848596

Nevertheless, there are few animal studies and in vitro studies demonstrating the role of natural extracts like irradiated green tea polyphenol, [19] proanthocyanidin-rich extract from grape seeds, [20] ellagic acid-rich pomegranate extract, [21] and coumarin extracts from the plant Angelica dahurica , [22] in inhibiting melanogenesis resulting in skin whitening thereby recommending these agents as oral preparations for skin whitening

In addition, SSd downregulates the expression of NF-B, upregulating fibroblast growth factor 2 (FGF2), a neurotrophic growth factor involved in regulating synaptic plasticity and neuronal growth (Chao et al., 2020)