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Arch Biochem Biophys 382:2027 [DOI] [PubMed] [Google Scholar] Yu BP, Yang R (1996) Critical evaluation of the free radical theory of aging
*Correspondence: Olga Golounina, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
PLoS ONE 5(12):e15234
Mutations in mtDNA caused by ROS can further exacerbate mitochondrial dysfunction, creating a vicious cycle of oxidative stress and energy deficits (40, 41)

Their findings revealed that intracellular copper ions are key factors in NLRP3 inflammasome assembly and subsequent activation of cytokines such as caspase-1 and IL-1
