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The New England Journal of Medicine, 392 , 16731683

Awad, K

Lower renal clearance and urinary excretion of lesinurad were associated with the degree of renal impairment
at this concentration, 0.1 mL drawn into an insulin syringe corresponds to 500 g of peptide

Lesinurad inhibits the uric acid transporter URAT1 in the proximal tubules of the kidney, 6 resulting in increased urinary excretion of uric acid and lower sUA