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The pathogen-centric theory emphasizes the direct roles of specific virulence factors, CARDS Tx, and adhesion mechanisms (98)

This may be along with general COX 1 and COX 2 specificity (24), with the pyloric sphincter less sensitive to COX 2 and the lower esophageal sphincter more sensitive, but ultimately both affected by inhibition of both COX 1 and COX 2

Targeting Ferroptosis to Iron Out Cancer

Unlike circumscribed gliomas, which have well-defined margins and generally better prognosis, diffuse gliomas are characterized by extensive invasion into normal brain tissue, limiting the effectiveness of surgical resection