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However, some refractory patients respond poorly to conventional immunotherapies and exhibit rapid disease progression, leading to higher rates of disability and mortality (5)

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Blood concentrations of triglycerides (3 trials) and pro-inflammatory leukotriene B4 (5 trials) were also decreased with supplemental omega-3 PUFA (156)

However, TMAO inhibited the activity of pyruvate dehydrogenase (PDH) and weakened the oxidation of pyruvate in mitochondria, which impaired production of ATP (101)