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Briefly, the DAPI staining was used to define the nuclear regions

CONCLUSION DISCLOSURE OF INTERESTS REFERENCES Ayer A, Tan SX, Grant CM, Meyer AJ, Dawes IW, Perrone GG

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Biochemical parameters profile simulation The biochemical parameters profile simulation was performed using the best overall spectral filters combination in PLS to illustrate the prediction quality of the models in one of the bioreactor assays, by applying the chemometric method that demonstrated relatively reduced predictive performance, and the most established one for this type of application in pharmaceutical bioprocesses