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Proteoforms of vimentin (VIM) also showed enrichment in control compared to frail samples

The ratios of /(1) hydroxylation were 8 and 7 for 9(10)-EpODA and 9(10)-EpOME, respectively, but decreased to 1.6 for 12(13)-EpOME

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Studies indicate that activation of TLR2/3/4/5 triggers the NF-B/NLRP3 pathway and the PI3K/Akt/mTORC1 signaling pathway, leading to microglial activation, neuroinflammation, and neuronal damage (147, 148)

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