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In Trimarchis study, the random allocation, blindness of patients and having a control group were almost impeccable (12)

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The protein is proteolytically cleaved to monomers that facilitate the aggregation of keratin intermediate microfibrils and collapse of the corneocyte cytoplasm (Steinert et al., 1981), after which the protein is further degraded to amino acids that aid in maintaining moisture in the stratum corneum (Harding and Scott, 1983