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The disease affects the brain, spinal cord, heart, muscles, and beta () cells of the pancreas, thereby characterising the disease by progressive neurodegeneration, musculoskeletal deformities, diabetes mellitus and hypertrophic cardiomyopathy ( FXN gene ( FXN gene codes for a very important mitochondrial protein called frataxin (Weng et al., 2020)
Indeed, exercise promotes fatty acid utilization through the up-regulation of carnitine acyltransferase shuttles (CPT-1 and CPT-2
Definition of a high-confidence mitochondrial proteome at quantitative scale
Phosphate deficiency induces the jasmonate pathway and enhances resistance to insect herbivory
These findings highlight the need to consider both genetic and environmental influences when investigating the etiology of depression [304]
