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Gingival crevicular fluid shows significantly reduced GSH concentrations and markedly elevated 4-HNE levels ( 2.4 The ferroptosis-inflammation vicious cycle drives chronic periodontitis Growing evidence indicates that ferroptosis can trigger inflammatory responses, while the inflammatory microenvironment further promotes ferroptosis, forming a self-amplifying vicious cycle that drives the persistent progression of chronic periodontitis

Insufficient folate and B12 supplies impair this pathway, leading to elevated tHcy levels (55)

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Inhibition of lovastatin- and docosahexaenoic acid-initiated autophagy in triple negative breast cancer reverted resistance and enhanced cytotoxicity

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