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Neely MD, Zimmerman L, Picklo MJ, Ou JJ, Morales CR, Montine KS et al

Since 2017, the ADA has recommended periodic vitamin B12 testing for individuals treated with metformin, especially in the presence of peripheral neuropathy or anemia [9]

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127 In skeletal muscle, TFEB supports mitochondrial homeostasis by activating mitophagy-related genes such as PINK1, PRKN , and BNIP3 , which are essential under metabolic or exercise-induced stress