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Juvenile models are particularly susceptible to these CNS changes during treatment

Future therapies for prevention of disc degeneration, targeted disc regeneration and biological modification of the degenerative cascade might prevent or reverse pathological changes across all spinal regions

DSIP is found endogenously in the hypothalamus, limbic system, pituitary gland, and several peripheral organs, a distribution pattern that suggests biological roles extending well beyond sleep alone

2022 Jul 12;27(14):4459

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