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The metabolites were heterogeneously distributed, so that only a subset of ASD individuals had high concentrations of any individual MDM, but most children with ASD had higher concentrations of one or more MDMs

Thus, there is a complexity in understanding the root cause, whether oxidative stress leads to mitochondrial dysfunction, or it is mitochondrial dysfunction that leads to oxidative stress [49,126,127]

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Bondanza A, Zimmermann VS, Rovere-Querini P, Turnay J, Dumitriu IE, Stach CM et al

Given that RS is less clearly defined and infrequently assessed in standard diagnostics, this constraint is especially pertinent when detecting it [62] ( Table 3 )