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Its main active ingredient, total dajizin triterpenes, reduces the expression of ACSL4 in the rat model of RA, increases the expression of glutathione and GPX4, and upregulates Kelch-like ECH-associated protein 1 and HO-1 in the Nrf2/HO-1/GPX4 pathway, indicating that total dajizin triterpenes can inhibit cell aberrant ferroptosis by suppressing lipid peroxidation and thus exert therapeutic anti-RA effects [168]
Consequently, ALA supplements are advisable to be consumed on an empty stomach to capitalize on the acidic stomach pH
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In the present study, the glutathione (GSH), Trx, and Glo systems were investigated to understand early events (0.53 h) that may determine cell fate
