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Foods high in B12 are animal products: meat, poultry, seafood, dairy, and eggs, with eggs having the least

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Therefore, despite coppers promoting effects on cell survival and proliferation, and the dependence of tumor cells on copper, inducing copper accumulation in cancer cells can specifically induce the production of higher levels of ROS in tumor tissues based on the sensitivity of cancer cells to ROS and the higher concentration of copper ions in cancer tissues

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Similarly, mice exposed to CUMS for 6 weeks showed an increased interferon-gamma (IFN-) and decreased anti-inflammatory IL-10 levels, demonstrating anti-inflammatory suppression with further pro-inflammatory activation (Jia et al., 2024)