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Cost : CNC machining can be more expensive than laser cutting due to the need for specialized tools, more setup time, and longer machining processes

Furthermore, distinct variations in the biosynthesis of the reduced form of glutathione (GSH) and other metabolites related to the cellular antioxidant defense were observed for different untreated Pt(II)-resistant ovarian cancer cell lines, namely, increased levels of GSH and taurine in C200 cells [12] and A2780 [13] cells, respectively, while GSH, hypotaurine and taurine levels were found to be decreased in PEA2 cells [14]

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These mutants showed a low basal activity, but their activity could not be stimulated by SAM-like wild-type (Fig

In fact a subsequent investigation found a lot of the data behind a lot of his ground-breaking research was entirely made up
