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It has been found that intracellular fumaric acid aggregation causes succination of GPX4 at cysteine 93, resulting in a decrease in GPX4 activity and sensitizing cancer cells to ferroptosis inducers (Kerins et al., 2018)

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Targeted dissolved metabolites, including organic acids, vitamins, organosulfur compounds, nucleosides, oligosaccharides, and free amino acids, also revealed diel patterns in the euphotic zone that were significantly cross-correlated with PAR in one or both years (Table 1 and Supplementary Fig