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Kannt A, Pfenninger A, Teichert L, et al

For people with MTHFR mutations, this conversion process can be inefficient, meaning they may not get the full benefit of the supplement

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Monitoring and follow-up Monitor clinically and repeat tests as indicated by the underlying condition Ongoing monitoring of liver function, renal function, and FBC as clinically indicated Regular review in primary care or specialist clinics for underlying conditions Patient advice: Patients should understand that elevated B12 is a marker requiring investigation rather than a condition requiring direct treatment

IPA Level How much of the health-supportive metabolite IPA your gut bacteria produce to keep your metabolism in balance