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While the induction of the MPTP has been considered to be a catastrophic feature of APAP-induced cell signaling, recent research suggests that this too could be adjusted depending on the dose of APAP, where treatment of animals with a low 150-mg/kg overdose of APAP resulted in transient JNK activation and reversible induction of the MPTP20, from which cells may be able to recover

doi: 10.1016/j.intimp.2022.108942 21

5 , 22732283 (1991) Kolb, A., Busby, S., Buc, H., Garges, S

Progress without Parity: Gender-Distribution of Cardiothoracic Surgical Society Awards

Clinical impact of sarcopenia assessment in patients with liver cirrhosis