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This occurs through multiple mechanisms

A one-way ANOVA revealed an almost significant main effect of NNMT inhibitor treatment on intracellular NAD + levels (F (5,6) = 4.131, P = 0.0568) (Figure 3B)

By blocking NNMT activity, 5-Amino-1MQ raises intracellular SAM levels and simultaneously elevates NAD+ precursor availability creating conditions that research has associated with reduced fat cell differentiation and improved metabolic signaling

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Wnt signalling pathway
