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Chemically, its rich in terpenoid compounds: thymoquinone (TQ, the best-studied), thymohydroquinone, thymol, carvacrol, and -hederin, which together are thought to underlie many of the antioxidant and anti-inflammatory effects reported in research.3 The use of black seed oil has a long history:3 Greco-Roman authors such as Hippocrates and Dioscorides referenced melanthion, the ancient Greek name for black seed oil

Mitochondrial glutathione transport: physiological, pathological and toxicological implications

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(PubMed) Shults CW, Oakes D, Kieburtz K, et al

IGF-1 has specific and stimulatory effects on granulosa cells, and it was reported to increase the expression of steroidogenic enzymes CYP11A1, 3-hroxysteroid dehydrogenase (3HSD), CYP19A1, along with IGF-1R, and FSHR gene expression (70)