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Its multi-pronged approach targets the underlying mechanisms of OA, offering not just symptomatic relief but also aiming to slow the disease's progression

For instance, the heparin-binding domain of heparin-binding epidermal growth factor (HB-EGF) has been employed to enhance the retention of IGF-1 in cartilage in vivo , resulting in increased therapeutic efficacy in a rat medial meniscal tear model of OA

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