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These changes in hippocampal circuitry are mirrored in the amygdala of APOE4 models, where early synaptic deficits further underscore the critical role of synaptic dysfunction in AD progression (Klein et al., 2010)

Acknowledgments The authors would like to acknowledge all contributions to the field of sensing, cell wall biogenesis, and immune response to Candida albicans that could not be included in this review due to space limitation

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