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doi: 10.3389/fphys.2026.1764165 Received 15 January 2026 Revised 29 December 2025 Accepted 19 January 2026 Published 09 February 2026 Volume 17 - 2026 Edited by Khosrow Kashfi, City University of New York, United States Reviewed by Jerzy Beltowski, Medical University of Lublin, Poland John Toscano, Johns Hopkins University, United States Updates Copyright 2026 Hirabayashi, Sasaki, Ohno, Takayama, Yamada and Hanaoka

PGC-1 also co-activates ERRs to enhance mitochondrial biogenesis and glucose utilization (Jornayvaz and Shulman, 2010

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